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Pathology of Genetically Engineered and Other Mutant Mice

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An updated and comprehensive reference to pathology in every organ system in genetically modified mice

The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, and includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice.

The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice.

Readers will also benefit from:
A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice
An exploration of concepts related to validating animal models, including the Cinderella Effect
Practical discussions of basic necropsy methods and grading lesions for computational analyses
Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues
As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
The editors

John P. Sundberg, DVM, PhD, DACVP, is Professor at The Jackson Laboratory in Bar Harbor, Maine, USA and an Adjunct Professor in the Department of Dermatology, Vanderbilt University Medical Center in Nashville, TN, USA.

Peter Vogel, DVM, PhD, DACVP, is Director of the Veterinary Pathology Core Laboratory at St. Jude Children’s Research Hospital in Memphis, Tennessee, USA.

Jerrold M. Ward, DVM, PhD, DACVP, FIATP, is a consultant at Global VetPathology, Montgomery Village, Maryland; an Adjunct Faculty member at The Jackson Laboratory, Bar Harbor, Maine, USA and Adjunct Professor in the Department of Biomedical Sciences at Cornell University College of Veterinary Medicine in Ithaca, New York, USA.

Autor: John P. Sundberg (Editor), Peter Vogel (Editor), Jerrold M. Ward (Editor)

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Contributors List

Preface and Acknowledgements

Chapter 1. Introduction to Mouse Pathology
Jerrold M. Ward, Peter Vogel, John P. Sundberg

Chapter 2. The Mouse Online: Open Mouse Biology and Pathology Data Resources for Biomedical Research
Dale A. Begley, Paul N. Schofield, and John P. Sundberg

Chapter 3. Mouse Genetic Nomenclature; the Underpinning of Mouse Genetics
John P. Sundberg, Dale Begley, Melissa Berry, Michelle N. Perry, David Shaw, and Paul N. Schofield

Chapter 4. Discovering and Validating Mouse Models of Human Diseases: The Cinderella Effect
John P. Sundberg, Jerrold M. Ward, Peter Vogel, and Paul N. Schofiel

Chapter 5. Embryos, Placentas, and Neonates
Brad Bolon and Jerrold M. Ward

Chapter 6. Ciliopathies
Peter Vogel and Laura L. Janke

Chapter 7. Hematopoietic and Lymphoid Tissues
Harm HogenEsch and John P. Sundberg

Chapter 8. Hematolymphoid Neoplasms
Jerold E. Rehg

Chapter 9. Immunodeficient and Humanized Mice
Sara F. Santagostino, Sébastien Monette, Alessandra Piersigilli, Virginia L. Godfrey, and Harm HogenEsch

Chapter 10. Skin, Hair, and Nails
John P. Sundberg, Lloyd E. King, Jr., Raoul V. Kuiper

Chapter 11. Mammary Gland
Alexander D. Borowsky and Robert D. Cardiff

Chapter 12. Respiratory System
Jerry M. Ward and John P. Sundberg

Chapter 13. Gastrointestinal Tract
Jerrold M. Ward, Piper M. Treuting, M. Kay Washington

Chapter 14. Cardiovascular System
Kathleen Gabrielson, Akash Behera, Polina Sysa-Shah, Tyler J. Creamer, and Timothy Cooper

Chapter 15. Liver and Pancreas
Maria L.Z. Dagli, Lucas M. Chaible, and Katja Steiger

Chapter 16. Neuromuscular System
Peter Vogel, Laura L. Janke, and Heather S. Tillman

Chapter 17. Endocrine System
Krista Marie DuBray La Perle

Chapter 18. Kidney and Urinary Bladder
Jeffrey B. Kopp, Cory F. Brayton, Jeffrey Everett, Avi Z. Rosenberg, Jerrold M. Ward

Chapter 19. Female Reproductive Tract
Darlene Dixon and Alexander Nikitin

Chapter 20. Male Reproductive Tract
Sue E. Knoblaugh, Hibret A. Adissu, Colin McKerlie, Robert D. Cardiff

Chapter 21. Nervous System
Jessica M. Snyder, Katherine N. Gibson-Corley, and Enrico Radaelli

Chapter 22. Eye and Ear
Heather Tillman, Laura Janke, Jerold Rehg, Peter Vogel

Chapter 23. Bones and teeth
Peter Vogel, John P. Sundberg, Cheryl Ackert-B